Aging, Telomeres, and Yoga: New Study by Elizabeth Blackburn and Dean Ornish

by Baxter

A while back, we reported on an interesting potential marker in the body for aging of the cells connected to the genes called a telomere (see Stressed Mind, Stressed Cells and Science, Aging and Yoga). A telomere is like a tail on the end of DNA strands found in our cells, and an enzyme called telomerase influences the length and activity of the telomere. Studies done a few years ago by a Dr. Elizabeth Blackburn at UCSF in San Francisco began to show a connection between telomeres and cell longevity—the longer the telomere, the longer the cell life. Her work garnered her a Nobel Prize in Medicine.

Telomere Caps

Now Dr. Blackburn has teamed up with Dr. Dean Ornish to see what effect his life-style changes approach to prostate cancer has on telomeres and telomerase activity. Dr. Ornish has already shown that a combination of dietary changes (vegan diet with less than 10% fat per day), exercise in the form of walking for 30 minutes most days, and stress management tools that include regular yoga asana and breath work, mindfulness meditation and once a week group stress reduction sessions can reverse heart disease and diabetes, and can stabilize prostate cancer and stop its progression.

In their most recent study, published in Lancet Oncology (see Effect of comprehensive lifestyle changes on telomerase activity and telomere length in men with biopsy-proven low-risk prostate cancer: 5-year follow-up of a descriptive pilot study), the two researchers looked at how the lifestyle program impacted the cellular genetic level in regards to telomere length and enzyme activity. What they found was that the 10 men studied had longer telomeres in the short (as quickly as three months!) and long run, if they stuck to the program, and the 25 men who were controls had shorter telomeres. And they also looked at gene activity in their ten study subjects, and found that 500 genes were turned on, and all were beneficial, according to Ornish. 

Even though telomeres may be an indicator of longer cell life, and by extension, longer overall lifespan, this has not been definitively concluded, so more studies will need to be done, looking at much larger numbers of people. But the early evidence is promising, and even if the telomere/aging cell theory does not pan out, it seems evident that yoga, diet, exercise and stress management do have significantly positive impacts on health, disease progress or remission, and are therefore worth the effort. And as Dr. Ornish noted, his study participants found the lifestyle plan easy to follow, with 85-90% compliance, much better than most pharmaceutical based treatment plans. Why, you might ask? Well, has he says, it’s because it’s pleasant and comprehensive and “most people feel so much better they change their lifestyle.”

To read more, you can check out articles at ucsf.edu and today.com—among others—which reported these new findings.

STRESS, TELOMERES, AND AGING

by Nina

In his next post, Brad will be writing about one of the several competing theories about aging: Nobel Prize winner Dr. Elizabeth Blackburn’s theory of the relationship between aging and telomeres (the protective caps at the ends of our chromosomes). Dr. Blackburn believes that telomere length is an indicator of the age and vitality of a cell, and that psychological stress actually ages cells, which can be seen when telomere length is measured.

We thought you might be interested in Dr. Blackburn’s work because she is so convinced about the effects of stress on cellular aging that she is studying the effects of meditation and yoga on telomeres. So for those of you who would like to learn a bit about her work before Brad’s post, here is a little background information. As a start, you can find a brief interview with Dr. Blackburn here. If you’ve got an hour or so, you can listen to her lecture on “Chromosome Ends and Diseases of Aging” here.

Gaudi Mosaic by Brad Gibson

Throughout your life, your cells may reproduce many times to repair and strengthen their host organs, to grow or to fight disease, and the telomere at the end shrinks each time the cell divides and duplicates itself. A chemical called telomerase helps restore a portion of the telomere with each division, but after 10 to 50 divisions or so (the number varies by tissue type and health, and biologists still do not understand the system well), the telomere gets so short that the cell is no longer able to replicate. Because some cells or tissues in our body (skin, blood cells, etc.) continue to replicate and be replaced as we age, or to be repaired after injury, if the progenitor cells needed for these processes cannot replicate due to telomere shortening, this can contribute to the aging process and increase our susceptibility to disease. See here for a short article on this.

For several years, Dr. Blackburn has been conducting research on the relationship between stress and telomere length. According to her, there is so much evidence that psychological stress actually ages cells that she and her colleagues have been studying the effects of mindful meditation on telomere length. See here for a full academic paper entitled “Can meditation slow the rate of cellular aging?” I've read that as a result of these studies, Dr. Blackburn has taken up meditation as regular practice.

To be continued....